What Is Biochemistry - lead Poisoning
Lead poisoning
Lead poisoning can be detected via elevation of the level of lead in the serum with evidence of basophilic stippling and microcytic hypochromic anemia on the peripheral blood smears.
Patient with lead poisoning may also present with elevation of the FEP level.
Lead poisoning is presented with symptoms and signs such as encephalopathy, colicky abdominal pain, myalgia, decreased libido, constipation, irritability, poor concentration, anorexia, peripheral neuropathy wrist drop, ankle drop, weakness of extensor and formation of lead line which is a bluish pigmentation on the gum tooth line.
Patient may also present with lead lines on the epiphyses of the long bone on the x ray film.
Lead poisoning in the blood may lead to inhibition of the sulfhydryl-dependent enzymes ( ferrochelatase or gamma aminolevulinic acid ) that involved in the synthesis of heme.
Elevation of the lead may lead to disturbance of the heme synthesis which may lead to increase in the FEP. This will lead to oxidative damage to organs system ( degeneration of the axon and demyelination, hypertension, renal toxicity and increase hemolysis with decrease in erythrocytes time survival.
Patient with lead poisoning may be treated with chelation with (2,3-dimercaptosuccinic acid) succimer and reduction of exposure to lead.
Patient may also need to be treated with dimercaprol, penicillamine and calcium edetic acid as well as vitamin C.
Lead poisoning can be detected via elevation of the level of lead in the serum with evidence of basophilic stippling and microcytic hypochromic anemia on the peripheral blood smears.
Patient with lead poisoning may also present with elevation of the FEP level.
Lead poisoning is presented with symptoms and signs such as encephalopathy, colicky abdominal pain, myalgia, decreased libido, constipation, irritability, poor concentration, anorexia, peripheral neuropathy wrist drop, ankle drop, weakness of extensor and formation of lead line which is a bluish pigmentation on the gum tooth line.
Patient may also present with lead lines on the epiphyses of the long bone on the x ray film.
Lead poisoning in the blood may lead to inhibition of the sulfhydryl-dependent enzymes ( ferrochelatase or gamma aminolevulinic acid ) that involved in the synthesis of heme.
Elevation of the lead may lead to disturbance of the heme synthesis which may lead to increase in the FEP. This will lead to oxidative damage to organs system ( degeneration of the axon and demyelination, hypertension, renal toxicity and increase hemolysis with decrease in erythrocytes time survival.
Patient with lead poisoning may be treated with chelation with (2,3-dimercaptosuccinic acid) succimer and reduction of exposure to lead.
Patient may also need to be treated with dimercaprol, penicillamine and calcium edetic acid as well as vitamin C.
