What Is Genetic Disorder - Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia
There are a few forms of multiple endocrine neoplasia ( MEN) which include multiple endocrine neoplasia I ( MEN I ) and multiple endocrine neoplasia IIa (MEN IIa) as well as multiple endocrine neoplasia IIb (MEN IIb).
Multiple endocrine neoplasia I (MEN I) may lead to formation of tumor such as pituitary adenoma, parathyroid hyperplasia, parathyroid adenoma and pancreatic islet tumor (
Zollinger Ellison syndrome / peptic ulcer due to gastrinoma).
Multiple endocrine neoplasia I ( MEN I) is an autosomal dominant condition due to mutation of the MEN I gene on chromosome 11.
Multiple endocrine neoplasia IIa and IIb may present due to uncontrollable activation of the tyrosine kinase receptor ( RET proto - oncogene) that involved in cellular growth signaling.
Patient is predisposed to neoplasia.
Multiple endocrine neoplasia IIa and IIb ( MEN 11a and MEN IIb) are autosomal dominant disorders due to mutation of the RET proto - oncogene on chromosome 10.
Multiple endocrine neoplasia IIa may present with medullary carcinoma of the thyroid gland, hyperplasia of the parathyroid gland and pheochromocytoma.
Multiple endocrine neoplasia IIb may present with medullary carcinoma of the thyroid gland, pheochromocytoma and mucocutaneous neuromas of the gastrointestinal tract, eyes or skins.
Patient may need to be treated by removing the carcinoma / tumor. Surgical excision is considered.
There are a few forms of multiple endocrine neoplasia ( MEN) which include multiple endocrine neoplasia I ( MEN I ) and multiple endocrine neoplasia IIa (MEN IIa) as well as multiple endocrine neoplasia IIb (MEN IIb).
Multiple endocrine neoplasia I (MEN I) may lead to formation of tumor such as pituitary adenoma, parathyroid hyperplasia, parathyroid adenoma and pancreatic islet tumor (
Zollinger Ellison syndrome / peptic ulcer due to gastrinoma).
Multiple endocrine neoplasia I ( MEN I) is an autosomal dominant condition due to mutation of the MEN I gene on chromosome 11.
Multiple endocrine neoplasia IIa and IIb may present due to uncontrollable activation of the tyrosine kinase receptor ( RET proto - oncogene) that involved in cellular growth signaling.
Patient is predisposed to neoplasia.
Multiple endocrine neoplasia IIa and IIb ( MEN 11a and MEN IIb) are autosomal dominant disorders due to mutation of the RET proto - oncogene on chromosome 10.
Multiple endocrine neoplasia IIa may present with medullary carcinoma of the thyroid gland, hyperplasia of the parathyroid gland and pheochromocytoma.
Multiple endocrine neoplasia IIb may present with medullary carcinoma of the thyroid gland, pheochromocytoma and mucocutaneous neuromas of the gastrointestinal tract, eyes or skins.
Patient may need to be treated by removing the carcinoma / tumor. Surgical excision is considered.
